Biomarkers And Prediction Of Disease - 1538 Words

Biomarkers and prediction of disease Biomarkers (also known as biological markers) are a measurement of a biological sample that is used for the prediction of a subject’s disease rate, early detection of disease, and to also enhance the diagnostic classification. (Simon, 2011). In order for biomarkers to be considered useful, they must meet specific criteria, including; accuracy, reliability, meaning that the results are stable when they are repeated numerous times, and therapeutic impact of early intervention (Ge Wang, 2012). The literature that will be investigated in this paper include, the specific biomarkers in cardiovascular disease, how nutrition can intervene with these biological markers, and also including the pros and cons of using biomarkers to predict disease. However, this review will not explore other diseases in relation to biomarkers. Biomarkers are referred to as a measurement of a biological sample, are a very useful piece of information that is obtained in order to predict a patient’s disease state, (Eapen, Ghasemzadeh, MacNamara, Quyyumi, 2014). Eapen et al. (2014) also states that biomarkers are used for three general purposes, those being; screening, diagnosis and prognosis. The â€Å"ideal† biomarker will fluctuate with the state of the disease, meaning that if the disease worsens or improves the biomarker will increase or decrease respectively (Eapen et al., 2014). Eapen et al., (2014) quotes In the case of a diagnostic biomarker, Bayes theoremShow MoreRelatedCharacteristics Of An Ideal Biomarker1807 Words   |  8 PagesVery recently, Biomarkers have got a higher level of interest in regards to clinical aspects and science with passing years. Biomarkers have the potential to be beneficial with regards to primary, secondary and tertiary prevention.There are several characteristics of an ideal biomarker which have been earlier stated such as them being easy as well as safe to measure. This includes the low cost of them which must include that of the follow up tests. Additionally, there must be scientific proof indicatingRead MoreEssay On Hepatitis C Mono911 Words   |  4 Pagesspecificity, AUROC curve, positive and negative predictive values of selected cut off values of Hepa-Index for prediction of significant hepatic fibrosis (≠¥ F2), severe hepatic fibrosis (≠¥ F3), and cirrhosis (F4) are summarized in table 3 respectively. Discussion: Serum fibrosis biomarkers are promising methods for staging hepatic fibrosis and monitoring both progression [17] and regression of liver disease in chronic hepatitis C [18]. Although their use is limited by being non-specific for the liver [19]Read MoreDirect Analytical Sample Quality Assessment (DASQ) for Biomarker Investigation: Qualifying CSF Samples978 Words   |  4 Pagesand the changes in their concentrations directly reflect the internal milieu of the brain: it offers a unique window to search for new biomarkers and to improve early diagnosis of neurological diseases [1-3]. However, the complexities of the brain and human neurological disorders represent a severe roadblock to identify novel neurological biomarkers. A biomarker can be defined as a biochemical, pharmacological or physiological, indicator of a specific biological state or of a defined biological stageRead MoreArgumentative Papers On Pspa876 Words   |  4 PagesProstate-specific antigen can no longer be consi dered as a classical biomarker whose levels are directly correlated with increasing stage of the disease. Moreover, the relationship with tumor grade remains unclear [6] Also classical prognostic tools based on pretreatment PSA levels, such as Partin tables [7] and Kattan nomograms [8], have become less reliable because of the continuous shift toward earlier stages of the disease at diagnosis. According to Thompson et al. [9], there is no true PSA cutoffRead MoreSymptoms And Treatment Of Rheumatoid Arthritis1568 Words   |  7 PagesRheumatoid arthritis (RA) is characterized by chronic, erosive polyarthritis and the presence of numerous autoantibodies in the serum and synovial fluid and membrane. Rheumatoid arthritis (RA) is a systemic inflammatory autoimmune disease that manifests in multiple joints of the body. The inflammation leads to erosions in the cartilage and bone and can cause joint deformity. Individuals with RA often experience pain and swelling of the joints. It was estimated in 2005 that 1.5 million peopleRead MoreLiver Biopsy Essay802 Words   |  4 PagesChronic liver diseases and liver biopsy. Chronic liver diseases encompass many different causes, including viral infections, nonalcoholic fatty liver disease (NAFLD), alcohol abuse, primary sclerosing cholangitis, primary hemochromatosis, and autoimmune disease. All of these precipitate chronic damage to the liver via necroinflammation and subsequent cellular injury and accumulation of extracellular matrix (ECM) proteins distorting the hepatic architecture by forming hepatic fibrosis with abnormalRead MoreNursing Case Study973 Words   |  4 Pagescontents), many patients do not develop ARDS. Current research is evaluating the presence of biomarkers both to improve recognition and explore possible treatments. Treatment is currently supportive focusing on minimizing damage further lung damage. Management currently focuses on ventilator strategies and conservative fluid therapy, (Taylor, Chambers, Liu, 2017). Due to the complexity of this disease, informatics plays a large role in optimizing care for ARDs in the SICU. Three ways informaticsRead MoreIn The Last 100 Years There Were Major Challenges In The1688 Words   |  7 PagesIn the last 100 years there were major challenges in the field of mental health in regards to a lack of international consensus on diagnostic categories for mental disorders between the most used manuals the (ICD) international classification of diseases and (DSM) diagnostic and statistical manual of mental disorders which are still elusive until now and still struggle to fulfil its purpose (Hickie, Scott McGorry, 2013) as both of them depends on observation of mainly middle-aged people withRead MoreTuberculosis ( Tb ) Is A Airborne And Contagious Infectious Disease Caused By Mycobacterium Tuberculosis Bacilli Essay1641 Words   |  7 PagesChapter One: Introduction Tuberculosis (TB) is a airborne and contagious-infectious disease caused by Mycobacterium tuberculosis bacilli, usually establishes its infection in the lungs and known as pulmonary tuberculosis also can affect other sites and known as extrapulmonary tuberculosis (Rodrigo,2006; Comas,2009). Human Tuberculosis (TB) is a major global public health problem for both developed and developing countries , is the second cause of death in worldwide, after the human immunodeficiencyRead MoreThe Biology Of A Cell Mass1676 Words   |  7 Pagesclassifications since there is no reflection of the entire tumor clinical heterogeneity. Therefore, they are not sufficient in making predictions for the adequate treatment of patients. The chances of survival for the patients suffering from cancer normally depends on the timely detection of the disease and in this perspective, the highly specific and sensitive methods of curing the disease take play. Notably, oncology can be revolutionaliuze3d t hrough the development of the bio affinity particle and in the process